Pharm Ingredients
Piroctone Olamine Powder
Piroctone Olamine Powder Manufacturers
Piroctone olamine is a highly effective and safe pyridone derivative with broad-spectrum bactericidal and fungicidal activity, significantly inhibiting Gram-positive, Gram-negative, and Malassezia bacteria. As a core active ingredient in the global anti-dandruff and scalp care industry, it reduces dandruff and relieves itching at its source by inhibiting fungal energy metabolism, and is non-sensitizing and non-mutagenic. Kintainutri® Extracts focuses on supplying 99% high-purity piroctone olamine powder, helping clients create differentiated and compliant personal care products.
Contact us | Item | Specification | Test Method |
|---|---|---|
| Characters | White to pale yellow crystalline powder | Visual |
| Solubility | Water (0.10g+10ml): non-soluble; Methanol (1.00g+10ml): soluble |
Solubility Test |
| pH (1% in water) | 8.5~10.0 | pH Meter |
| Melting range ℃ | 133~136 | GB/T 21781-2008 |
| Residue on ignition | ≤0.2% | GB/T 9741-2008 |
| Purity | ≥99% | HPLC |
| Loss on Drying | ≤0.3% | Gravimetric Method |
| Monoethanolamine | 20.0~21.0% | HPLC |
| Methanol | ≤500ppm | Headspace-GC |
| Ethyl acetate | ≤500ppm | Headspace-GC |
| Nitrosamine content | ≤50ppb | LC-MS/MS |
| Pb | <10mg/kg | ICP-MS |
| Hg | <1mg/kg | ICP-MS |
| As | <2mg/kg | ICP-MS |
| Cd | ≤5mg/kg | ICP-MS |
| Storage | Stored in cool and dry place | |
| Shelf life | 2 years when properly stored |
How To Make Piroctone Olamine Powder?
Piroctone Olamine Powder Benefits
Piroctone Olamine Benefits For Hair
Piroctone olamine is a highly effective and safe antifungal agent that precisely inhibits the activity and proliferation of Malassezia, the main culprit behind dandruff, by chelating iron ions, thus addressing dandruff and scalp itching at their source. Unlike some traditional anti-dandruff agents, it has a strong affinity for keratin, continuing to adhere to the scalp and exert its effects even after rinsing. It is very gentle on the scalp, with low irritation, resulting in thicker and stronger hair. Furthermore, it regulates sebum secretion, provides antioxidant benefits, improves the scalp microenvironment, and promotes hair growth. Our product boasts high purity and stability, making it suitable for high-end anti-dandruff, scalp care, and anti-hair loss shampoos, and an ideal choice for creating differentiated products.
Piroctone Olamine Skin Benefits
OCT offers dual benefits in skin care for conditions such as facial seborrheic dermatitis (FSD): In terms of antifungal activity, it effectively reduces inflammatory bacterial colonization on the scalp and face by inhibiting ergosterol synthesis and disrupting the cell wall integrity of fungi such as Malassezia; in terms of anti-inflammatory and soothing effects, it significantly relieves symptoms such as erythema, scaling, burning sensation, and itching, improving skin barrier function.
Clinical studies show that 0.5%–1% concentrations of piroctone olamine powder, used alone or in combination, achieve excellent cosmetic results and are non-photosensitive, allowing for unrestricted use in summer. As a B2B ingredient, it is suitable for antifungal and anti-inflammatory compound systems in facial and scalp care, helping to reduce dependence on corticosteroids and meeting the demand for gentle yet highly effective personal care formulations.
Piroctone Olamine Antifungal
Octopirox acts as a broad-spectrum antifungal agent by penetrating the fungal cell membrane and forming a complex with intracellular iron ions (Fe²⁺/Fe³⁺), thereby inhibiting mitochondrial energy metabolism and blocking the energy supply required for fungal growth.
This mechanism differs from conventional azole drugs (which inhibit ergosterol synthesis), thus maintaining good antifungal activity against some azole-resistant Candida strains (in vitro MIC as low as 0.125–0.5 μg/mL). It also exhibits activity against Gram-positive/gram-negative bacteria, and animal studies show low toxicity and high safety. As a B-end raw material, it is suitable for the development of anti-dandruff piroctone olamine shampoos and pharmaceutical-grade antifungal formulations.
Piroctone Olamine Antibacterial
Piroctone olamine exerts its antibacterial efficacy through a dual mechanism of action: on the one hand, it significantly increases the level of reactive oxygen species (ROS) in bacterial cells, inducing oxidative stress and leading to oxidative damage to biomolecules such as DNA, proteins, and lipids; on the other hand, it disrupts the integrity of bacterial cell membranes, increasing membrane permeability and causing leakage of important intracellular substances such as proteins, ultimately leading to bacterial death.
When loaded onto a nanocarrier, its antibacterial activity is significantly enhanced, with the minimum inhibitory concentration (MIC) against Streptococcus mutans decreasing from 53.33 μg/mL in the free state to 2.66 μg/mL, representing approximately a 20-fold increase in efficacy.This mechanism is completely different from conventional azole drugs (which inhibit ergosterol synthesis), effectively targeting drug-resistant strains and exhibiting good biocompatibility, making it suitable for the development of antibacterial formulations in oral care and personal care products.
What Is Piroctone Olamine Powder Used For？
Anti-dandruff and Anti-itch
Piroctone olamine powder reduces dandruff and scalp itching at the source by inhibiting the energy metabolism of Malassezia. Clinical studies show that shampoos with a concentration of 0.5% to 0.75% can significantly relieve itching and reduce dandruff after several days of use, with effects lasting until discontinuation. Its excellent solubility supports the development of piroctone olamine shampoos, piroctone olamine conditioners, and moisturizers; it is stable within a pH range of 3 to 9 and compatible with most cosmetic ingredients, making it an ideal compliant alternative after ZPT was banned in the EU.
piroctone olamine deodorant
Piroctone olamine has broad-spectrum inhibitory activity against both Gram-positive and Gram-negative bacteria, effectively reducing the proliferation of odor-causing bacteria on the skin surface. Clariant's internal testing shows that its deodorizing effect at a 0.1% concentration is superior to traditional triclosan. Suitable for various formulations including roll-on, spray, stick, and foot deodorant cream, it is gentle and low-irritant, non-photosensitive, and can be used without restrictions in summer.
Acne Treatment Products
Piroctone olamine salt has a clear inhibitory activity against Propionibacterium acnes and is suitable for acne gel, lotion, and piroctone olamine cleanser formulations. The recommended addition level is ≤0.2% (residual type). It exerts its antibacterial effect by disrupting the integrity of bacterial cell membranes and inducing oxidative stress. Compared to traditional ingredients such as benzoyl peroxide, it is less irritating and has anti-inflammatory and soothing properties, helping to improve the redness and swelling associated with acne.
Is Piroctone Olamine Powder Safe?
According to the EU SCCNFP assessment, piroctone olamine has been proven to have a reliable safety profile: it is non-sensitizing, non-genotoxic, and non-teratogenic. In rats, the oral NOEL after 90 days is 100 mg/kg/day, and the dermal absorption rate is only about 4.5%. Rabbit skin irritation tests showed no irritation at concentrations of 2%–3%, and only mild and transient eye irritation. Human facial trials (1% cream, 4 weeks) showed good tolerability. Historically, the highest approved safe concentration is 1% for rinse-off products and 0.5% for other products. This ingredient has a good safety record with decades of use without adverse reaction reports; however, a complete toxicological profile is required for EU approval of the 1% residual concentration.
Where Can I Buy Piroctone Olamine Powder?
Kintainutri® is committed to providing global personal care brands with 99% high-purity, highly stable piroctone olamine powder raw materials. Our products adhere to strict control over production processes and quality standards, and we offer complete technical documentation and regulatory support, helping clients quickly launch differentiated products in various fields such as dandruff control, anti-itch, deodorization, and acne treatment. Whether it's transparent shampoos, leave-on serums, or new deodorants and anti-acne formulas, Kintainutri® provides reliable raw material guarantees and professional technical services. Contact us for free samples.
*Kintainutri® Promise All Products: Non-Irradiated / Non-ETO/ Treat by Heat Only / Non-GMO
Reference:
[1]: https://en.wikipedia.org/wiki/Piroctone_olamine
[2]: https://pmc.ncbi.nlm.nih.gov/articles/PMC9486417/
[3]: https://pmc.ncbi.nlm.nih.gov/articles/PMC4833761/
[4]: https://pmc.ncbi.nlm.nih.gov/articles/PMC9365318/
[5]:https://pmc.ncbi.nlm.nih.gov/articles/PMC6704200/
[6]: https://ec.europa.eu/health/ph_risk/committees/sccp/documents/out162_en.pdf
[1]: https://en.wikipedia.org/wiki/Piroctone_olamine
[2]: https://pmc.ncbi.nlm.nih.gov/articles/PMC9486417/
[3]: https://pmc.ncbi.nlm.nih.gov/articles/PMC4833761/
[4]: https://pmc.ncbi.nlm.nih.gov/articles/PMC9365318/
[5]:https://pmc.ncbi.nlm.nih.gov/articles/PMC6704200/
[6]: https://ec.europa.eu/health/ph_risk/committees/sccp/documents/out162_en.pdf
FAQ
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Is piroctone olamine powder good for hair?
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Is piroctone olamine powder same as zinc pyrithione?
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